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A novel plant-based diet may have the potential to completely reverse age-related and pathological changes in brain functions in a rat model, claims a new study.

It has been shown that animals on a diet containing amylose — the major starch-like component found in plants — have enhanced cognitive functions. The authors of the current study wanted to see if these diet-induced cognitive improvements could be achieved without employing the dietary modification, thus making it easier to adopt for human diets.

Cognitive decline is a major factor in Alzheimer’s disease, and ageing is one of the major risk factors.

In the current study, the researchers looked at the relationship between amylose administration and changes in oxidative stress, inflammation and mitochondrial damage in the brain of rats aged 16 and 22 months.

They found that amylose treatment significantly lowered the oxidative stress and proinflammatory markers, and enhanced the mitochondrial function in the rat brains.

“These findings lead us to suggest a novel dietary intervention which may be effective in the maintenance of cognitive function in the ageing brain,” said Dr Changwen Li, from the University of Sydney.

“If further evidence supports that, this type of dietary intervention could be adopted by the general population, which may prevent the deterioration of cognitive function.”

Although the study shows the potential of amylose to improve brain function, this is not a new finding.

The results are presented as an abstract of the Annual Conference of the Society for Neuroscience and the Australasian Neuroscience Society which is taking place on 26 and 27 April in Boca Raton, Florida.

It will be published in the Society for Neuroscience’s journal Current Biology on the 2 May.

The authors have no conflicts of interest to declare.

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