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Treatment of high-risk and poor-risk myeloma with bortezomib and cyclophosphamide.
The standard chemotherapy for myeloma is still melphalan-based. Bortezomib is a second-generation proteasome inhibitor and has shown promising results in patients with relapsed or refractory myeloma. The aim of this study was to assess the efficacy and safety of bortezomib with cyclophosphamide for patients with newly diagnosed or relapsed myeloma. Patients were treated with bortezomib (1.3 mg/m(2) IV) and cyclophosphamide (200 mg/m(2) IV) on days 1, 4, 8, and 11. Twenty-three patients with newly diagnosed myeloma (13 men and 10 women; median age, 65 years; range, 47-79 years) and 28 patients with relapsed myeloma (18 men and 10 women; median age, 65 years; range, 44-78 years) were enrolled in this phase II trial. The median progression-free survival (PFS) was 3.5 months (95% CI, 2.9-3.9), with 6% (1 of 18 patients) of the patients with newly diagnosed myeloma and 32% (9 of 28 patients) of the patients with relapsed myeloma having complete response (CR). The median overall survival (OS) was 5.3 months (95% CI, 4.0-6.5), with 7% (1 of 15 patients) of the patients with newly diagnosed myeloma and 23% (6 of 28 patients) of the patients with relapsed myeloma having CR. The most common nonhematologic grade 3/4 toxicities were fatigue, nausea, and vomiting. Infections occurred in 11 patients (48%), with 2 (9%) patients requiring hospitalization for infection. Overall, bortezomib-cyclophosphamide was well tolerated but demonstrated limited activity as a single agent in this population of patients with myeloma.Main menu

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Create, modify and edit macro tasks in MACRO TASK MANAGER.
What’s New:
– Added “Only when using buttons” option in the task groups that the tasks can be executed only if you click on the button.
– Added “Repeat task every” option to the task. Now you can add a task that repeats every day, weekly or monthly.
– Added ability to delete a task group when all the task in the group are not needed anymore.
Bug fixes and Improvements.
Macro Categories:
– Keyed action
– Actions with no option
– Actions with just text
– Pre-programmed actions
What’s New:
Macro categories are useful for managing groups of macros. They can be named in any way and they can have a structure.
You can easily edit and remove them in the Macro Manager window.
Use them to:
– Allow to manage groups of macros
– Organize your macros
– Create a macro category for your macros
Macro Categories:
– macro Categories
Bug Fixes and Improvements:
– Fixed the crashes in Macros for some customers
– Ability to move and resize the form in dialog boxes
– Added the option “close” to the main window after the message “Continue?” appeared
– Added the option “only one macro category”
– Fixed the incompatibility between firefox and firefox add-ons
Changelog:
2.0.1.1
– Fixed the crash with the “OnTextChanged” event of the combobox “Task Group”
– Fixed the crash with the “OnTextChanged” event of the combobox “Repeated task”
2.0.1
– Added the option “ButtonType” to the combobox “Repeated task”
2.0
– Fixed the bug that could prevent the windows of some customers from opening
– Fixed the bug in the combobox “task group” in the task assignment.
– Fixed the bug in the combobox “ButtonType” in the task assignment.
– Fixed the bug in the combobox “repeated task”.
– Fixed the bug in the combobox “repeat every”.
– Fixed the bug in the combobox “task group”.
– Fixed the bug in the combobox “task group”.
– Added a new combobox “repeated task”.
– Added a new combobox “repeated task

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